I was on and off Zyprxa for a few years. It works really well for agitation. I didn't feel bombed out, I could still goto work on 10mg. However, it does cause weight gain, mostly from a massive desire to eat sugar and fat but I felt it put it on regardless of what I ate sometimes. Recently I was put on it for mania while IP and it did not bring me down and I put on 8lb in 2 weeks so I asked my pdoc for a switch. He put me on Abilify and I lost the weight and also came down from manic psychosis in a week.