Hi, I'm 53. When I hit my 50's my anxiety and depression absolutely skyrocketed. "Happy' hypomania turned into a dysphoric, nervous, miserable, anxious mania. Medication stopped being as effective as it had been. I felt like I was completely losing my mind. Awful, awful. I am now on a lot of meds, have gone through menopause...a little bit better than I was, but I sure hope I improve even more after some time has passed.