Dear Mysterious_Lion--I hear a lot of sadness, low self-esteem feelings in your post. When we are depressed, (you sound a bit depressed), it can be harder to connect with others. Plus you're describing stress at work and having to deal with difficult people. Please go easy on yourself. Perhaps your friend didn't respond because she is also dealing with these things. At a better time, in a better situation you might connect with these friends or perhaps, someday, someone new will come along where you just connect naturally. I am sorry you feel anxious about it all...I say keep sending people nice messages -- it might make them feel good and maybe one of those "non close friends" may become a close friend someday or your friend will return your fb message soon.