I'm on Effexor XR 150mg and mirtazapine 30mg.

The Effexor is the only medication that's ever helped but it only helps for maybe 6 months and it stops having an effect whatsoever. No other SSRIs or SNRIs help at all.

The mirtazapine does essentially nothing, but it at least limits my insomnia to two-three nights a week instead of all week.

I'm also on some anxiety meds for when things get too bad, but they don't even make me groggy or limit my depression induced anxiety, so welp to those.