Since about July last year I have been taking Ritalin. Started on 10mg and slowly moved up to my current dose of 60mg. During that time I got very depressed and sometimes the Ritalin would lift it for a few hours but it was hit and miss. In the end I was put on an AD Cymbalta and that helped more than the Ritalin. Ritalin does come with a risk of mania. I got manic in October but my doctor thought it was the Cymbalta. I was temporarily taken off the Ritalin but still manic so taken off Cymbalta. Anyway, that is my experience.