SSRI antidepressants send me straight into irritated, raging mania. I absolutely cannot take anything like zoloft. Wellbutrin is one of the only antidepressants I can take that actually works great and I can take it without triggering those manic episodes. I've been on Wellbutrin XL for years, on varying dosages. I take it in combination with Latuda and have had no weight gain. I hope it works out for you!