The only real med I had a problem with (erectile dysfunction) was Lexapro. I was on Wellbutrin (prescribed by my gp) for awhile with no problems. I actually quit smoking while on it. The psych arnp switched me to cymbalta, because he was worried about the potential for seizures. I have epilepsy.

No problem with the cymbalta. Right now it's my brain that's causing the problems. As my mood lifts (it's slowly happening), things should get somewhat back to normal working order.

And from what you're describing, I'd say yes that it's major. I'm not a doctor though. Best to discuss with yours'.