Lately the sedation and dosage inverse relationship is coming up a lot in the forum chats related to Seroquel. People swear that its more sedating at low doses and gets less and less sedative as the doses gets higher. They explain this bizarre behaviour of serouel at low doses by attributing it to its higher affinity for the histamine receptors. As far as sedation is concerned i'm okay with that.

My concern is that, Histamine receptors are also directly linked to appetite regulation, and also the regular use of antihistamines is linked to senility at old age (or so i've read). Given that at low doses, such as mine 50 mg, and its high affinity to bind to the histamine receptors, Does that mean it'll also cause more elevation in appetite at low doses than high doses?

given its antihistamine properties and its link to possible degeneration of Brain function , should i maybe look to an alternative medicine in the long term scheme?

I understand that i should be asking all these questions to my doctor. But i live in India, and unfortunately the doctors for treating mental health disorders are scant out here, probably because the occurrence of all such mental health disorders is extremely rare out here.

The few Pdoc's that i do find, are usually not that concerned about explaining the side effects ( or sometimes even admitting that there are any side effects). Like for example my old pdoc denied that Seroquel increases appetite at all. Even after taking it for a few months when I told him plain that IT IS very much elevating my appetite, i feel it every night when i want to binge on carbs, and i cant stop it, he still refuses to accept it. Says its the best AP when it comes to not causing weight gain and what im feeling is all in my mind, not real. So you see my dilemma. I rely on my own research to protect myself from all the nasty side effects that comes with psych meds. But that doesn't always work, theres just so much research out there, its overwhelming, and confusing often times. So psych central has been a blessing for me. People are very informative in here. I trust the personal anecdotes and experiences shared by members more than any doctor or research article. So any advice, thoughts you can share will be very much appreciated.