CQ - The dose at which people respond to SSRIs like Zoloft™ (sertraline) varies widely. The vast majority of people
with depression respond to either 50mg or 100mg per day. I find that anxiety disorders respond to lower doses, while
those with panic disorder and OCD respond to higher doses.

Lack of energy is just one depressive symptom. You have to look at the group. The symptoms tend to respond to
treatment in varying degrees, and at different times in treatment. For instance, "in general", sleep and appetite are the first
to return (1 to 3 weeks); then energy and initiative begin to return (2 to 5 weeks); then the resolution of most of the other
depressive symptoms (4 to 16 weeks).

In your case, energy and initiative should have begun to resolve, although you may not get a complete restoration of
energy until a majority of the depression is resolved. This may involve more than just the medication working; you may
need some counseling to help with the issues that caused the depression, in the first place.

If I were you, I'd wait one more week and if there isn't much more improvement, you may want to ask you doc about a
dosage increase. I am all in favor of increasing antidepressant dosages slowly. This way you avoid many of the start-up
side effects (eg. headache, nausea, diarrhea, insmonia, etc.) that cause so many people to discontinue these drugs early. I
feel that this slower route to alleviation of depressive symptoms produces a longer lasting, more thorough base with which
to work on what caused the depression, in the first place.

I hope that this is of some help. - Cam