This is just my personal experience but my biggest regret was not taking time off to care for my father, and thinking that work would somehow help me deal with it all, when he had cancer. That was 14 years ago. Fast forward to now, and I resigned from a busy national job which paid well but meant lots of travel, so I could care for my now 85 year old mother. I work from home and part time and made major adjustments to how I live and the money I spend. I don't regret that at all. My parents are everything to me too. Work seems so much less important to me now than it did. I just see it as a way to earn money to pay bills. I'm 50 this year. My heart goes out to you in this situation, it's so hard. I hope you find the answer you need, and some peace.