I've been taking 400 mg one to two times a day for breakthrough anxiety and some DM neuropathy beginning in my feet. It does have a "loopy" effect sometimes. When it doesn't. It helps me think more clearly. As another poster put, it takes the stress out of stress. At least for me. My husband has been on it 6 years for bi-polar (and I believe PTSD) and he says he can't even tell he takes it any more. My sister takes megadoses for severe neuropathy and nerve pain for years and she's the same.