I cannot speak for Latuda, but in terms of meds that make you tired, I usually take them about 30 minutes before I go to bed. If I try to take Seroquel before going out, I just can't. 30 minutes later I feel like I am going to pass out. So I would say that anything that causes drowsiness should be taken before bed, but not too late as it will probably make you feel drowsy in the morning.