I've managed to lose some of the clozapine weight and stop gaining it by taking metformin. I could have lost more if my doctor weren't concerned my blood sugar would go too low on a higher dose.

It's really frustrating. Most of the clozapine weight has been in my belly and nothing seems to change that my clothes from a year ago don't fit.

I am not even all that hungry. I think Seroquel weigh gain was easier for me because I did get hungry at night on it. With this I'm not nearly as hungry but I still gained weight (and would gain more without metformin).

But for me I'd rather have the annoying weight gain than not have clozapine.