Yeah, clozaril has to be used consistently or you have to go back through the gradual dose increases all over again. And missing a dose is very bad. I missed a dose one night and half a dose the next when my cat was so sick last week and was sick for 2 days as a consequence.

But I don't want to scare anyone off. With meformin my weight is about the same as it was when I started it a year ago today. The weight is distributed differently but I'm also menopausal which is another annoyance. I hate the weight issues and really wish I could take more metformin or more topamax but I can't.

And the thing is the med WORKS. I've never done so well so long. I probably had 8 months of relative stability (stable for me we say) and I'm depressed now but I've had to put both my cats to sleep in the last 2 months so there is a reason. Even then the depression sucks but I have lots of room to adjust the clozaril to help it and the clozaril will stop it. I've never really had a med that I could have that kind of confidence in. So it is totally worth it.