I did great on Seroquel XR and found it to be much less sedating than the regular Seroquel. I was on 800 mg of Seroquel XR and able to get up in the morning with my daughter for school and get her ready to go on time and function without a problem. I was able to function normally on vacation at Disney World without sleepiness or being tired. I just took it every night before I went to bed. I found it was good for my depression, too. Besides, Latuda, I was the most stable on Seroquel XR than any other meds - as far as mood stabilizer or AP. I did take it with a combination of other meds, too. Of course, everyone reacts to meds differently but that was my experience with it. I hope you have good results.