Hello Trace14: I don't know the answer to your question. I would think there could certainly be such a thing as a fibro flare-up. But I don't know. I know about chronic ailments though. I have a ruptured disc that impinges on the sciatic nerve. So I have sciatica primarily in the left leg although I also experience some discomfort in the right. I also have Meniere's Disease & tinnitus. Plus, since I'm an older person, I've begun experiencing the onset of some other strange stuff. I'm not receiving treatment for any of it...