I'd take lunesta over seroquel, personally. Sedatives over the long haul aren't the best idea, in general. There was a meta-analysis a couple years ago that found higher rates of cancer for people who routinely use sedatives of any sort, so...that's a problem, clearly.

Different people respond to the z hypnotics, and other psych drugs, differently. Some take them nightly for years, no problem. Some find that they stop working rather quickly. There are case reports of dosage escalation and other signs of addiction with the z hypnotics, but I don't think its as big an issue as with the benzodiazepines. Tapering can be rough for some people, but a lot of people can do fairly rapid tapers without major problems.

Sedative use can cause or worsen depression over the long haul. So can long term benzodiazepine use, whether its a daytime tranquilizer or a night time sedative.

I hope you can find something that helps.