You really need too try anything , not saying anything? But there are new studies and have found that Suboxone can help with treatment resistance depression, it is mainly for opiate addiction, I am on it I was addicted too Hydrocodone 12 years I was on 12 mg which is pretty high I'm weaning off now on 6mg . Psychiatrist can prescribe Suboxone if they are approved and take required 1 day course,so get out research don't give up I been there , I'm telling you write me back i will tell you more info, but even if can't do that get on university hospital sites , they pay people too be in research programs check Emory Hospital.com it's in Georgia where I'm from , text me I will give all info 706-728-0451