I would say for me the depression is the worst I don't want to move, work, get out of bed, go out see people or talk to people. The manic side is bad too in that I say and do things I wouldn't normally do, make advances on people, get really irritable, start something but because my mind is going a thousand miles a second I just jump to the next thing not completing it. In short I think I fear the isolation I feel with depression more.