There is more to sorting out methylation cycle issues than just the MTHFR gene. If you look at it in isolation, and then supplement based on that, you can get into trouble.

However, in general, supplementing with Folate has the potential to correct some system-wide biochemical issues that could ultimately improve mood and brain function. Could be a MUCH better approach than doing drugs, which tend to throw biochemistry further out of whack. I would not trust a psychiatrist with this if my life depended on it. Functional Medicine docs all the way.