Everyone is different, and so are their reactions to a given med. Me, well, buproprion made me manic, and I mean raging manic. I didn't know I was bipolar at the time or I would never have taken it without a mood stabilizer. I was pissed off all.the.time. I was just as likely to threaten people as look at them. It was awful, and then when I quit taking it I was a mushy, pathetic hot mess. Never again, even though I'm on mood stabilizers now.