It depends on how your body is responding to the combo. Some drugs interact and can cause havoc. Do you feel your combo is working for you? Do you have intolerable side effects? I know the feeling though, like a walking rattling pharmacy. Along with my signature I take tramadol for pain, thyroxin for thyroid issues (thanks Lithium!) and tonnes of vitamins and supplements. I wonder how my stomach digests it all sometimes. Still, few side effects and positive results so I'm sticking with it.