I also have a friend of sorts, since 3 years. She also "changed" on me... before I realized she had a history of doing the exact same thing with other people in the past, and that she really did not change. She just appeared more healthy at the beginning and the closer we got the more of her problems she unleashed onto me. It was a lot of ups and downs during those years.
So I wonder if this could be the case of your friend, or if she is very obviously declining in health steadily.
I wish I knew what to do with friends like that. I don't want to be yet one more that leaves her but also she basically just used me. She could unleash 50 text messages while I was obviously busy then getting mad/sad that I "ignored and hated her". She asked for many favors yet never returned a single one. Also very emotionally unstable and off and on paranoid.
Once I tried for her not to text me for 2 days because as I explained I needed to be alone because we needed to put the dog down. It took 2 hours after we came home from the vet when she started the text slamming, "can I just ask this and that?" and then bam bam bam her usual issues that she told me a million times again. No respect at all.
In January she decided again I hate her because I did not engage so much in the text ramblings, and I told her just how it was, that I can't deal with anything right now, I need to be left alone for a bit. She said she never needs that so I don't. She needs company so the reason I didn't need hers was that I hated her. I told her I did not cuz I don't! But she took my quietness as hatred despite what I said and decided to cut all ties with me like blocking my phone number.
I don't think she understands other people have feelings, hers always come first. I don't think she understand that I might feel hurt by her blocking me, in her world I "started it".
I think people like these need TONS of help. They try to rely on friends and too much so, their friends becomes their helpers more than anything. I don't know how convince people they need serious help. My friend just tried her meds a few days then dumped them. The doctor was way too busy to even understand all her shortcomings that are NOT part of depression.
I don't think my friend has schizophrenia, I think she has strong anxiety with paranoia that stems from her thinking she is the center of the universe. She thinks everyone thinks of her all the time when in fact they could not care less. Also she has strong traits of autism and some kind of borderlineish behavior. What your friend has... well perhaps more than depression and it should be looked into. It gets really messy when lot of different psych symptoms are in the picture. More than a friend can handle.