I've taken both Wellbutrin and Prozac, but not in combination. Prozac gave me anxiety and motion sickness, but of course, different antidepressants have different effects on different people. I have bipolar II disorder (primarily depressive), so Prozac might work very differently for people who have depression or some other condition.

Right now, I take a low dose of Lexapro (escitalopram) with Lamictal (Lamotrigine). I have no side effects from the Lexapro and it gives me a gentle energy boost while the Lamictal stabilizes mood swings (e.g. teariness, irritability, hypomania).