I had the depo shot back in 2001. It threw me into menopause-like symptoms (hot flashes, no periods, overly emotional). I didn't get another one and had to wait for the first one to wear off. I went on th e mini pill after that. (I was breastfeeding.) Right now I've got the Mirena to lighten my periods. I haven't actually had a period in almost a year I think. I'm 45 in a couple weeks, but I'm not having any other menopause symptoms.