I was on serquel for a while. I experienced severe muscle twitching and if I was late in taking my meds I had a bobble-head feeling. I decided to go off the drug without my doctors permission and that was a big mistake. My bobble-head became unbearable and noticeable. I couldn't walk straight and was totally disorientated. I started taking the meds again and after a few days I was ok. I then consulted my dr and went off it very slowly, 1 fifth of a tablet reduction per month. It took ages, but I feel better now. I didn't like it at all. I am PTSD patient though and I don't think it was the correct meds for my condition, it might be the right stuff for you though. My brother is bipolar and swears by it. He only gets slight leg twitching.