A couple of things you mentioned resonated with me.
Firstly, don't be afraid to try new medications. There is no 'one size fits all' and what works for some will not work for others. I have been on several throughout my life. I know it's a pain having to start all over again each time but if you find the one that clicks, it is incredible.
Secondly, it is easy to beat ourselves up for not being happy despite what appears to be a perfect life. I have a wife, 2 children, lovely home, my health and eat 3 meals a day. I am aware a huge percentage of the world would kill for this. Sounds great ? I have suffered all my life. It doesn't matter what we have, our minds are the result of our childhoods. Mine was pretty awful, so despite the life I am leading now ('perfect' like your own) I suffer greatly with constant suicidal thoughts and belief that I am worthless.

Have you looked into your own childhood through any kind of counselling ?