I don't know if this is helpful, but when I was taking Seroquel in the morning (and a lot of it), I drank a lot of coffee and that helped a bit. If you suffer from anxiety, though, I wouldn't recommend too much coffee as it can make that worse (or at least it does with me). Best of luck with this. I know how challenging it is to take Seroquel during the day. Great to stave on mania, but SO sedating...