Hey I am James I take Zoloft 150mg, Adderall 20mg3×day , Klonopin 1mg bedtime and Suboxone 12mg no antidepressants have ever helped but psychiatrist are using Suboxone which is am opiate in small doses for treatment resistant depression. Also the Adderall helps I have bad ADHD, I also was opiate addict 12 years, I was self medicating cause I didn't accept I had mental health issues for years . But my point is psychiatrist are using Suboxone on normal non opiate addicted patients as well to aid antidepressants. I really feel this has kicked Zoloft in better, also Adderall has helped my organization skills, procrastinating, relationship problems,slot of other aspects. I am x addict so psychiatrist does keep close eye on me I had sign contract, agree for mother to hold meds she brings a week's at time,drug test, pill counts , therapy.I am 40 now I got diagnosed at 6 . But I'm not complaining about all the specifications I have too deal with too take meds cause been clean off hydrocodone (Vicodin) ,7 years now and live pretty normal life now ...