I feel for you, bluebicycle and can totally relate. I've been on various doses of Seroquel throughout the years (a lot of up and down lately though).....and I have experienced the good, the bad, and the ugly when it comes to this medicine. I recently asked my pdoc to lower it a little based on some appetite increases, some weight gain, involuntary shaking/twitching, and other side effects. Maybe that's why I'm hypo now, but I'm trying to work through it, rather than go up again. It sucks that nothing helps me sleep but Seroquel, and when hypo/manic, it's the only way I can get a few hours. Pdocs expect patients to take their meds for depression/stabilization, yet they make you depressed and de-stabilized as far as lowering self-image due to weight gain.

What dose are you on now?