I use to work for the Center for Human Services Development at the University of Maryland, a nonprofit (defunct now) that helped agencies focus and use their personnel and monies better, etc. and we had a lot of West Virginia members. My impression was that "transportation" was the big West Virginia problem. Even if they created jobs, the people had trouble getting to them because things are few and far between. I'd see if I could do some sort of fix-junk-cars/low-cost "taxi"/transportation service thing? You could have classes for teens/dropouts and they could learn to fix the cars (sort of like in "Grease" :-) and they could have jobs doing that once they learned and/or jobs as "drivers" along routes to pick up and take a couple people to/from work for less than what a for-profit organization would charge, etc. The more cars in a community the better the chance they'd need mechanics to "fix"/maintain them, etc. Just try to improve the transportation "system" in some way and create jobs for teachers, mechanics, drivers, etc.