I have been looking into alternative depression treatments, because I feel that my brain chemistry is out of wack and the ssri isn't helping much. As I was looking into SAM-E I came across an article on webmd claiming that taking SAM-E alongside your anti-depressant is more effective than the anti-depressant alone. I have to be skeptical, however, because it sounds like the study was done by the company that sells the SAM-E. It was very tempting to run out and buy SAM-E, but that is what they want people to do, as any hope is good hope while severely depressed. Does anyone have any SAM-E experiences that could help shine some light on whether it is indeed effective?

Here is the article SAM-e May Boost Effects of Antidepressants