Everyone is different but Wellbutrin helps me at 150 mg per day but made me absolutely manic at 300 mg per day. I tried 300 mg for four days in a row. I was getting 1-3 hours of sleep and the 4th night I barely got one hour of sleep. So I stopped taking that dose and slept OK the 5th night. It also made me more anxious. I still have the other 26 pills--if I ever need to pull an all nighter--I have the means.....