It depends on the meds, their side effects, and your physiology -- that is, how the side effects affect you.

For example, a lot of people say they feel energetic on Wellbutrin -- but it puts me to sleep. Even a small dose knocks me out cold.

Effexor gives me tremors. I have to take it in two doses twice a day. I have other meds that help me to get a good night's sleep.

I tried about 8 different antidepressants before finding one that worked, & a plan to take it that minimized side effect.