I take 200 mg Lamictal at night, right at bedtime, with all my other meds except levothyroxine. I take it on an empty stomach. I don't get any side effects from it. According to my pdoc you have to get off Lamictal gradually or it could trigger seizures....not sure what they do when you get "the rash". I imagine they do a quick taper but I'm just guessing at this. I drink quite a bit of alcohol and don't notice any different effects, so I'm different than LacunaCoiler...or maybe I'm just used to it