I take 200 mg twice a day morning and night without food. I've never had any problems out of lamictal, including the rash. I also take a dose of lithium with it, as well as Paxil, klonopin, and abilify. It's a good mix for me but everyone is different. I started off with just lamictal and it was effective until I got older and started having more mood disturbances. Good luck!