I currently take 200mg Lamictal and 80mg Latuda as my main psych combo.

The problem is that I've been dealing with low-grade depression almost the whole time I've been on this combo. I'd label it dysthymia, if that's appropriate. I'm still able to function, go to work, etc., but it seems life has no joy. Every couple weeks I will get a day or two of deeper depression, where I'd rather stay in bed than do anything else. On these days I force myself to go into work, but I don't get much done. In the evenings I'll stare at my phone rather than play games with my kids or whatever. It takes a tremendous amount of mental energy to do anything other than be a vegetable. At one point we went up to 300mg Lamictal. This had the effect of lifting the depression some and eliminated the periodic deeper depressions. Unfortunately the increased Lamictal began to give me blurry/double vision, and we had to go back down to 200.

At my most recent psychiatrist visit, my doc started talking about other med possibilities. He listed a whole bunch of different ones, and kind of put them on the back burner as options to look at.

Does anyone here have any similar experiences? I don't want to increase the Latuda, simply because there is very little clinical support for doses above 80mg showing any benefit in bipolar depression. I'm looking for any similar experience you may have had, and possibly any different cocktails that seem to have made a difference.

Recently we tried adding Wellbutrin to the existing combo with disastrous results. I began having insomnia, worsening depression, extreme anxiety, and suicidal thoughts. I tried to tough it out for three weeks, but eventually had to give it up.

I know we can't prescribe for each other, but I guess I'm looking to hear if anyone else has had this low-grade depression with some breakthrough, and what you've done about it. I'm open to other mood stabilizers, APs, and/or antidepressants. Either in conjunction with my current combo or as a partial or total replacement. I'm really open at this point, and am looking to take all suggestions under advisement.

Thanks for reading, and I'd love to hear anyone's cocktail and/or experiences that allow them to live life to the fullest.