I'm on Metformin and I've lost 20 pounds so far. That being said, it's not a silver bullet. I've had to have it adjusted twice because my blood sugar was too low.

I mentioned this in another forum, but I've accepted the body I have now. I have high cholesterol and diabetes due to all the weight gain from meds, also from the meds themselves. I'm doing the best I can to lose weight but it comes down to acceptance as well.