Two people recently told me to "calm down" in one situation each.

One is a friend who frequently tells me what to do and not to do, such as when driving to the cinema or when we replaced my car's wheel.
I don't release anger but it's mostly held inside. He further instructed and insisted on something and I told him that it's ok. He told me to calm down and I told him back to calm down with making a big deal out of small things.
It could be my depression, but I HATE! it when people make a big deal of small things, especially when it's over and over like that friend was doing.
That's why I eventually insisted that he not criticize me over small things because it annoys me.

Another is a pharmacist under whom I work as an assistant, among other pharmacists in each shift. I went to close his register and didn't look at his screen to see he's performing a bill. He told me to hold it and to "calm down". He's a pharmacist I kind of despise because he's driven by anger and I have problems dealing with other people's anger.

What do I do?