Yes. I have tried several meds that have hurt more than helped, both physically and mentally. I am skeptical of what psych meds actually do and I tend to deny my diagnosis, so I've gone without meds for months or years on end. Inevitably an episode comes (usually mixed) that is so unbearable I resort to medication again. Long term I hope I can taper off meds. But I know deep down that may not be in my best interest.