I don't know much about it, but 3 days ago, my pdoc and I were considering switching from Seroquel to either Vraylar or Rexulti. He said that Vraylar takes 3-4 weeks to be fully effective. I don't know how true that is or isn't, but that's a big reason I said no to it. I mean, if I miss a few doses in a row, then I'm screwed for 3-4 weeks. So I went with Rexulti