I understand this. A lot of it for me has to do with being "even." As in you're not really up or down but you're not really in the middle just kind of on the low side. It's weird how this works, we get our lives together, we are stable, yet we still feel empty.
I don't know what to advise, but I know exactly what you're talking about. The only thing that I can suggest is try to find something you love, something that you always wanted to do but never did. Trying something new always helped me.
Good luck!