Hrmm...have you tried toxin elimination in other areas of your life? Chemical cleaners, laundry detergents, body detergents & shampoos, etc? The more of those I stay away from the better I feel too. My pdoc calls it depression, but the the fatigue I've been fighting has nothing to do with that unless I've been depressed from birth. I wake up exhausted, always have. But the more natural my environment gets, the better quality sleep I get and it's finally starting to fall away. As far as meds go, I've found Zanaflex helpful too. My neurologist prescribed it for migraines and I wake up bright eyed and bushy tailed at 5am. Now if I could just replicate that without the pills.