I was lucky enough for the first SSRI I was prescribed to work wonderfully for me. I've been on Zoloft since I was 11, just in varying doses, and it has helped me get through so much. Of course I've done a lot of self-therapy and tried to improve my thinking patterns, but it just helps you do so (at least it has for me). I feel like Zoloft is the best SSRI for anxiety disorders (which is why I was prescribed them in the first place), so maybe it has just worked so well for me because my number one issue was anxiety and not depression or another disorder. Either way, I'm definitely one of the lucky ones to not have to juggle a bunch of antidepressants before finding one that helps. But once again, everyone reacts to every medication differently.