I was very depressed, and my doctor put me on a low dose of adderall. It worked immediately for me. I lost about 5 pounds, which didn't make much difference for me. I wouldn't have wanted it increased though, because it makes me a little anxious and irritable, and then I need a klonapin. I had to go off of it a few days ago because I'm going to be traveling to Thailand and they don't allow it there. My doctor put me on Ritalin and I'm back to feeling very depressed and lethargic. May be withdrawals, or might be the Ritalin itself. I'm not sure. The last medication I remember getting me out of depression, is lamictal, when I was put on it 10 years ago. Still taking it, but not completely helping anymore.