I was on 200mgs of Pristiq for 8 years. It did work pretty well for most of the time. The withdrawal is horrible though, it has been classed as the worse anti-d to come off. Even forgetting one day can have you paranoid and hallucinate and I have never been psychotic. Your bones will hurt so bad that those awful leg cramps you can get at night will be a welcome dream. I've gone back on Zoloft after a 10yr break and it seems to be going ok, it's always hard to tell when you have so much extra **** happening in your life if a med is working or not.