I took it with zoloft back before I was diagnosed. We never could find a dose that didn't over-sedate me or not work. But I was in grad school then and kept strange hours with lots of coffee and those things couldn't have helped. (The worst of it was having to take a bus for an 8 AM class on the diagonally opposite side of campus that left at 7:15 and I was barely awake while getting ready or even when I was in class). I eventually went off and back on my first cocktail of zoloft and remeron.