I feel for you. I had this same exact problem where I couldn't find a job to save my life because of a 5 year gap in employment history due to my MI combined with not having reliable transportation since bus systems where I live suck.

I would suggest doing one of two things:

Make up some B.S about how you had to care for a sick relative during your time off work and put on your Resume that you were a caretaker (but don't put relative) and all of the skills that somebody who is taking care of somebody who is ill (such as cooking, cleaning, communicating with doctors/nurses ETC) under your responsibilities. If inquired about in a job interview, say that the illness is something believable such as a long battle with cancer for example but don't get any specifics. I did this and took my resume to a temp agency and got a job literally the next day that I unfortunately, couldn't make it to because I had to be there at 5 AM and buses don't run that early and I don't have a car and I couldn't afford an Uber, therefore, I had to turn it down but doing so still makes getting an interview at the very least much easier.

A second option which is what I am personally doing now is do some type of freelance work online such as writing or other basic freelance tasks. Do a Google search on companies that pay you to write from your PC and you will find that many of them are easy to get into and best of all, no job interview! In the online freelance world, your skill level and ratings dictate what type of work you can find and how much you are paid and not a stupid piece of paper and an interview which is how it should be everywhere but I won't get further into how I feel about that haha

There's also Amazon Turks if you're desperate for cash. The pay is very little but the work is so easy an 8 year old could do it. They have you do things like basic Google searches, identifying pictures, making a post or finding a link for somebody, or other trivial online tasks which is perfect to do if you're desperate for money.

Finally, if you have a car and have had a driver's license for at least a year than becoming a driver for Uber or Lyft is a viable alternative because they will take you on without having to do any type of interviewing or resume submitting as long as you can prove that you have had your driver's license for at least a year, provide proof of insurance, and pass a background check, you are pretty much in and the pay is decent from what I've heard from somebody that I know who is actually an Uber driver.

If you need further advice, particularly if you are interested in freelance work or anything similar, feel free to hit me up anytime.