I started seroquel a couple weeks ago. For the past four years I've tried most ssris, wellbutrin, Latuda, abilify, zyprexa, you name it. I have a hypomanic episode once a yr, mostly in March/April. Then I'm depressed. Two weeks ago I started seroquel xr 300mg and now I feel "normal" if there is such a thing. I read seroquel has been approved for bipolar depression. Today I wrote a journal entry titled "Dear Seroquel." Yea I know it's weird but oh well. The thing I'm concerned about is will it cause weight gain? Anyone else have experience with seroquel?