I think the seroquel dosage reduction is contributing to this. I think Seroquel has a fairly short half-life, and 100mgs out of a 400mgs daily dose is a 25% cut, from day one. Add in to that Seroquel's effects--sedation, anti-agitation...tranquilizer stuff, basically (when you think about, Seroquel is basically cleaned up Thorazine, for the 21st century...)--and I think it makes sense, intuitively, that dropping the dose of a sedating tranquilizer could contribute to stuff like this.

I'm glad you've cut your dose a good bit. Over the long haul, neuroleptics should be at the LED--lowest effective dose. "Experts" figured that out once the TD lawsuits became a major issue. With the "atypicals," it seems that some doctors have chosen to go back to maintaining people on as much neuroleptic as the patient can tolerate (and sometimes more than that, as evidenced by the continuing popularity of cogentin...), which can actually cause a lot of problems--physical and psychiatric--over the long haul.

I dunno. Anytime psych drugs are reduced, there's a reaction, or at least that's how it's been for me and people I know. Most psych drugs suppress emotions, agitation, etc. to some extent, so when the dose of the drug(s) is cut, all that comes flooding back, plus whatever is going on in the brain.

I hope things get better in your world. My personal advice would be to accept where you are now and just try to get thru it, so you can stay on the lower dose of Seroquel. I know that's easy for me to say (clearly...I'm not living it...), but it does seem that most people do better by either tapering off neuroleptics or managing on the lowest dose possible in their situation.